The rabbit-sized heart was made from a patient’s own cells and tissues, using techniques that could help to increase the rate of successful heart transplants in future.
How it worked: A biopsy of tissue was taken from patients, and then its materials were separated. Some molecules, including collagen and glycoproteins, were processed into a hydrogel, which became the printing “ink.” Once the hydrogel was mixed with stem cells from the tissue, the researchers from Tel Aviv University were able to create a patient-specific heart that included blood vessels. The idea is that such a heart would be less likely to be rejected when transplanted. The study was published in the journal Advanced Science.
Let it flow: Until now, researchers have only been able to print simple tissues lacking blood vessels, so a 3D, fully vascularized engineered heart is a step in the right direction.
The impact: Heart disease causes one in four deaths in the US (about 610,000 people a year), and there’s a shortage of heart donors for transplants, so 3D-printed hearts could help solve a major issue.
Next steps: The team in Tel Aviv is planning on culturing the printed hearts and then transplanting them into animals. We’re still many, many years away from this being used for humans, though.
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- Associated Press | Tel Aviv University